FANDOM


DefinitionEdit

GT, also referred to as SPINA-GT, is an abbreviation for "gain of thyroid". It is a mathematical symbol for calculated secretory capacity of the thyroid gland. Calculation of GT is part of a structure-parameter inference approach, a method that is used e.g. in experimental thyroid research. The equations are derived from a mathematical model of thyrotropic feedback control.

CalculationEdit

\hat G_T  = {{\beta _T (D_T  + [TSH])(1 + K_{41} [TBG] + K_{42} [TBPA])[FT_4 ]} \over {\alpha _T [TSH]}}

\hat G_T  = {{\beta _T (D_T  + [TSH])[TT_4 ]} \over {\alpha _T [TSH]}}

\alpha _T: Dilution factor for T4 (reciprocal of apparent volume of distribution, 0.1 l-1)
\beta _T: Clearance exponent for T4 (1.1e-6 sec-1)
K41: Dissociation constant T4-TBG (2e10 l/mol)
K42: Dissociation constant T4-TBPA (2e8 l/mol)
DT: EC50 for TSH (2.75 mU/l)

Reference range Edit

1.41 - 8.67 pmol/sec (in adult humans)

see also: GD, SPINA

Web LinksEdit

ReferencesEdit

  1. Dietrich, J., M. Fischer, J. Jauch, E. Pantke, R. Gärtner und C. R. Pickardt (1999). "SPINA-THYR: A Novel Systems Theoretic Approach to Determine the Secretion Capacity of the Thyroid Gland." European Journal of Internal Medicine 10, Suppl. 1 (5/1999): S34.
  2. Dietrich, J. W. (2002). Der Hypophysen-Schilddrüsen-Regelkreis. Entwicklung und klinische Anwendung eines nichtlinearen Modells. Berlin, Logos-Verlag.
  3. Rosolowska-Huszcz D, Kozlowska L, Rydzewski A (2005). Influence of low protein diet on nonthyroidal illness syndrome in chronic renal failure. Endocrine. 27(3):283-8
  4. Dietrich, J. W., A. Stachon, B. Antic, H. H. Klein, and S. Hering (2008). "The AQUA-FONTIS Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome." BMC Endocrine Disorders 8 (13). PMID 18851740.

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.